2017


Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter.
Radic-Sarikas B, Halasz M, Huber KVM, Winter GE, Tsafou KP, Papamarkou T, Brunak S, Kolch W, Superti-Furga G.
Sci Rep. 2017 Jun 8; 7(1):3091. PMID: 28596528

Global survey of the immunomodulatory potential of common drugs.
Vladimer GI, Snijder B, Krall N, Bigenzahn JW, Huber KVM, Lardeau CH, Sanjiv K, Ringler A, Berglund UW, Sabler M, de la Fuente OL, Knöbl P, Kubicek S, Helleday T, Jäger U, Superti-Furga G.
Nat Chem Biol. 2017 Jun; 13(6):681-690. PMID: 28437395

TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML.
Valent P, Herndlhofer S, Schneeweiß M, Boidol B, Ringler A, Kubicek S, Gleixner KV, Hoermann G, Hadzijusufovic E, Müllauer L, Sperr WR, Superti-Furga G, Mannhalter C.
Oncotarget. 2017 Apr 4; 8(14):23061-23072. PMID: 28416739

Next generation of network medicine: interdisciplinary signaling approaches.
Korcsmaros T, Schneider MV, Superti-Furga G.
Integr Biol (Camb). 2017 Feb 20; 9(2):97-108. PMID: 28106223

Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KV, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Májek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Sørensen J, Kubicek S.
Cell. 2017 Jan 12; 168(1-2):86-100.e15. PMID: 27916275

NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors.
Byrgazov K, Kastner R, Gorna M, Hoermann G, Koenig M, Lucini CB, Ulreich R, Benesch M, Strenger V, Lackner H, Schwinger W, Sovinz P, Haas OA, van den Heuvel-Eibrink M, Niemeyer CM, Hantschel O, Valent P, Superti-Furga G, Urban C, Dworzak MN, Lion T.
Leukemia. 2017 Jan; 31(1):237-240. PMID: 27573554

Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities.
Radic-Sarikas B, Tsafou KP, Emdal KB, Papamarkou T, Huber KV, Mutz C, Toretsky JA, Bennett KL, Olsen JV, Brunak S, Kovar H, Superti-Furga G.
Mol Cancer Ther. 2017 Jan; 16(1):88-101. PMID: 28062706



2016


Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.
Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R.
J Clin Invest. 2016 Dec 1; 126(12):4482-4496. PMID: 27797343

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.
Martins R, Maier J, Gorki AD, Huber KV, Sharif O, Starkl P, Saluzzo S, Quattrone F, Gawish R, Lakovits K, Aichinger MC, Radic-Sarikas B, Lardeau CH, Hladik A, Korosec A, Brown M, Vaahtomeri K, Duggan M, Kerjaschki D, Esterbauer H, Colinge J, Eisenbarth SC, Decker T, Bennett KL, Kubicek S, Sixt M, Superti-Furga G, Knapp S.
Nat Immunol. 2016 Dec; 17(12):1361-1372. PMID: 27798618

Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity.
Gorelik A, Heinz LX, Illes K, Superti-Furga G, Nagar B.
J Biol Chem. 2016 Nov 11; 291(46):24054-24064. PMID: 27687724

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.
Tortola L, Nitsch R, Bertrand MJ, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM.
Cell Rep. 2016 Sep 20; 16(12):3414. PMID: 27653700

Crystal structure of mammalian acid sphingomyelinase.
Gorelik A, Illes K, Heinz LX, Superti-Furga G, Nagar B.
Nat Commun. 2016 Jul 20; 7:12196. PMID: 27435900

NANS-mediated synthesis of sialic acid is required for brain and skeletal development.
van Karnebeek CD, Bonafé L, Wen XY, Tarailo-Graovac M, Balzano S, Royer-Bertrand B, Ashikov A, Garavelli L, Mammi I, Turolla L, Breen C, Donnai D, Cormier V, Heron D, Nishimura G, Uchikawa S, Campos-Xavier B, Rossi A, Hennet T, Brand-Arzamendi K, Rozmus J, Harshman K, Stevenson BJ, Girardi E, Superti-Furga G, Dewan T, Collingridge A, Halparin J, Ross CJ, Van Allen MI, Rossi A, Engelke UF, Kluijtmans LA, van der Heeft E, Renkema H, de Brouwer A, Huijben K, Zijlstra F, Heisse T, Boltje T, Wasserman WW, Rivolta C, Unger S, Lefeber DJ, Wevers RA, Superti-Furga A.
Nat Genet. 2016 Jul; 48(7):777-84. PMID: 27213289

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.
Sdelci S, Lardeau CH, Tallant C, Klepsch F, Klaiber B, Bennett J, Rathert P, Schuster M, Penz T, Fedorov O, Superti-Furga G, Bock C, Zuber J, Huber KV, Knapp S, Müller S, Kubicek S.
Nat Chem Biol. 2016 Jul; 12(7):504-10. PMID: 27159579

Identifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry.
Müller AC, Giambruno R, Weißer J, Májek P, Hofer A, Bigenzahn JW, Superti-Furga G, Jessen HJ, Bennett KL.
Sci Rep. 2016 Jun 27; 6:28107. PMID: 27346722

SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1.
Rebsamen M, Superti-Furga G.
Autophagy. 2016 Jun 2; 12(6):1061-2. PMID: 26431368

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.
Tortola L, Nitsch R, Bertrand MJ, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM.
Cell Rep. 2016 May 17; 15(7):1481-92. PMID: 27160902

Functional crosstalk between membrane lipids and TLR biology.
Köberlin MS, Heinz LX, Superti-Furga G.
Curr Opin Cell Biol. 2016 Apr; 39:28-36. PMID: 26895312

Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A.
Gorelik A, Illes K, Superti-Furga G, Nagar B.
J Biol Chem. 2016 Mar 18; 291(12):6376-85. PMID: 26792860

Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells.
Pathria G, Garg B, Borgdorff V, Garg K, Wagner C, Superti-Furga G, Wagner SN.
Cell Death Dis. 2016 Mar 10; 7:e2135. PMID: 26962685

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.
Bigenzahn JW, Fauster A, Rebsamen M, Kandasamy RK, Scorzoni S, Vladimer GI, Müller AC, Gstaiger M, Zuber J, Bennett KL, Superti-Furga G.
Mol Cell Proteomics. 2016 Mar; 15(3):1139-50. PMID: 26933192

A Surface Biotinylation Strategy for Reproducible Plasma Membrane Protein Purification and Tracking of Genetic and Drug-Induced Alterations.
Hörmann K, Stukalov A, Müller AC, Heinz LX, Superti-Furga G, Colinge J, Bennett KL.
J Proteome Res. 2016 Feb 5; 15(2):647-58. PMID: 26699813

Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth.
Peter B, Winter GE, Blatt K, Bennett KL, Stefanzl G, Rix U, Eisenwort G, Hadzijusufovic E, Gridling M, Dutreix C, Hoermann G, Schwaab J, Radia D, Roesel J, Manley PW, Reiter A, Superti-Furga G, Valent P.
Leukemia. 2016 Feb; 30(2):464-72. PMID: 26349526

Germline RBBP6 mutations in familial myeloproliferative neoplasms.
Harutyunyan AS, Giambruno R, Krendl C, Stukalov A, Klampfl T, Berg T, Chen D, Milosevic Feenstra JD, Jäger R, Gisslinger B, Gisslinger H, Rumi E, Passamonti F, Pietra D, Müller AC, Parapatics K, Breitwieser FP, Herrmann R, Colinge J, Bennett KL, Superti-Furga G, Cazzola M, Hammond E, Kralovics R.
Blood. 2016 Jan 21; 127(3):362-5. PMID: 26574608

Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.
Valent P, Groner B, Schumacher U, Superti-Furga G, Busslinger M, Kralovics R, Zielinski C, Penninger JM, Kerjaschki D, Stingl G, Smolen JS, Valenta R, Lassmann H, Kovar H, Jäger U, Kornek G, Müller M, Sörgel F.
J Innate Immun. 2016; 8(2):111-20. PMID: 26845587

Profiling of Small Molecules by Chemical Proteomics.
Huber KVM, Superti-Furga G.
Methods Mol Biol. 2016; 1394:211-218. PMID: 26700051



2015


Enhancing cognate target elution efficiency in gel-free chemical proteomics
Radic-Sarikas B, Rix U, Stukalov A, Gridling M, Müller AC, Colinge J, Superti-Furga G, Bennett KL.
EuPA Open Proteom. 2015 Dec; 9: 43-53

Gene essentiality and synthetic lethality in haploid human cells.
Blomen VA, Májek P, Jae LT, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J, Superti-Furga G, Brummelkamp TR.
Science. 2015 Nov 27; 350(6264):1092-6. PMID: 26472760

Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia.
Royer-Bertrand B, Castillo-Taucher S, Moreno-Salinas R, Cho TJ, Chae JH, Choi M, Kim OH, Dikoglu E, Campos-Xavier B, Girardi E, Superti-Furga G, Bonafé L, Rivolta C, Unger S, Superti-Furga A.
Sci Rep. 2015 Nov 24; 5:17154. PMID: 26598328

Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.
Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A.
Immunity. 2015 Nov 17; 43(5):974-86. PMID: 26588782

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.
Huber KV, Olek KM, Müller AC, Tan CS, Bennett KL, Colinge J, Superti-Furga G.
Nat Methods. 2015 Nov; 12(11):1055-7. PMID: 26389571

Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis.
Blüml S, Sahin E, Saferding V, Goncalves-Alves E, Hainzl E, Niederreiter B, Hladik A, Lohmeyer T, Brunner JS, Bonelli M, Koenders MI, van den Berg WB, Superti-Furga G, Smolen JS, Schabbauer G, Redlich K.
Arthritis Res Ther. 2015 Aug 26; 17:230. PMID: 26307404

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KV, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G.
Nat Chem Biol. 2015 Aug; 11(8):571-8. PMID: 26167872

The promise and peril of chemical probes.
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.
Nat Chem Biol. 2015 Aug; 11(8):536-41. PMID: 26196764

A Call for Systematic Research on Solute Carriers.
César-Razquin A, Snijder B, Frappier-Brinton T, Isserlin R, Gyimesi G, Bai X, Reithmeier RA, Hepworth D, Hediger MA, Edwards AM, Superti-Furga G.
Cell. 2015 Jul 30; 162(3):478-87. PMID: 26232220

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death.
Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M, Superti-Furga G, Stockwell BR.
ACS Chem Biol. 2015 Jul 17; 10(7):1604-9. PMID: 25965523

A Modular Synthesis of Modified Phosphoanhydrides.
Hofer A, Cremosnik GS, Müller AC, Giambruno R, Trefzer C, Superti-Furga G, Bennett KL, Jessen HJ.
Chemistry. 2015 Jul 6; 21(28):10116-22. PMID: 26033174

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses.
Köberlin MS, Snijder B, Heinz LX, Baumann CL, Fauster A, Vladimer GI, Gavin AC, Superti-Furga G.
Cell. 2015 Jul 2; 162(1):170-83. PMID: 26095250
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NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.
Licciardello MP, Müllner MK, Dürnberger G, Kerzendorfer C, Boidol B, Trefzer C, Sdelci S, Berg T, Penz T, Schuster M, Bock C, Kralovics R, Superti-Furga G, Colinge J, Nijman SM, Kubicek S.
Oncogene. 2015 Jul; 34(29):3780-90. PMID: 25263445

Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome.
Dikoglu E, Alfaiz A, Gorna M, Bertola D, Chae JH, Cho TJ, Derbent M, Alanay Y, Guran T, Kim OH, Llerenar JC Jr, Yamamoto G, Superti-Furga G, Reymond A, Xenarios I, Stevenson B, Campos-Xavier B, Bonafé L, Superti-Furga A, Unger S.
Am J Med Genet A. 2015 Jul; 167(7):1501-9. PMID: 25808063

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.
Heinz LX, Baumann CL, Köberlin MS, Snijder B, Gawish R, Shui G, Sharif O, Aspalter IM, Müller AC, Kandasamy RK, Breitwieser FP, Pichlmair A, Bruckner M, Rebsamen M, Blüml S, Karonitsch T, Fauster A, Colinge J, Bennett KL, Knapp S, Wenk MR, Superti-Furga G.
Cell Rep. 2015 Jun 30; 11(12):1919-28. PMID: 26095358
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Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network.
Sana TG, Baumann C, Merdes A, Soscia C, Rattei T, Hachani A, Jones C, Bennett KL, Filloux A, Superti-Furga G, Voulhoux R, Bleves S.
MBio. 2015 Jun 2; 6(3):e00712. PMID: 26037124

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.
Lorenz S, Deng P, Hantschel O, Superti-Furga G, Kuriyan J.
Biochem J. 2015 Jun 1; 468(2):283-91. PMID: 25779001

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.
Fauster A, Rebsamen M, Huber KV, Bigenzahn JW, Stukalov A, Lardeau CH, Scorzoni S, Bruckner M, Gridling M, Parapatics K, Colinge J, Bennett KL, Kubicek S, Krautwald S, Linkermann A, Superti-Furga G.
Cell Death Dis. 2015 May 21; 6:e1767. PMID: 25996294

The RNA-binding protein HuR/ELAVL1 regulates IFN-β mRNA abundance and the type I IFN response.
Herdy B, Karonitsch T, Vladimer GI, Tan CS, Stukalov A, Trefzer C, Bigenzahn JW, Theil T, Holinka J, Kiener HP, Colinge J, Bennett KL, Superti-Furga G.
Eur J Immunol. 2015 May; 45(5):1500-11. PMID: 25678110

KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.
Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, Ciechanover A.
Cell. 2015 Apr 9; 161(2):333-47. PMID: 25860612

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G.
Nature. 2015 Mar 26; 519(7544):477-81. PMID: 25561175
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Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC.
PMID: 25713392

Targeting a cell state common to triple-negative breast cancers.
Muellner MK, Mair B, Ibrahim Y, Kerzendorfer C, Lechtermann H, Trefzer C, Klepsch F, Müller AC, Leitner E, Macho-Maschler S, Superti-Furga G, Bennett KL, Baselga J, Rix U, Kubicek S, Colinge J, Serra V, Nijman SM.
Mol Syst Biol. 2015 Feb 19; 11(1):789. PMID: 25699542



2014


Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.
Willmann KL, Klaver S, Doğu F, Santos-Valente E, Garncarz W, Bilic I, Mace E, Salzer E, Conde CD, Sic H, Májek P, Banerjee PP, Vladimer GI, Haskoloğlu S, Bolkent MG, Küpesiz A, Condino-Neto A, Colinge J, Superti-Furga G, Pickl WF, van Zelm MC, Eibel H, Orange JS, Ikincioğulları A, Boztuğ K.
Nat Commun. 2014 Nov 19; 5:5360. PMID: 25406581

Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics.
Gridling M, Ficarro SB, Breitwieser FP, Song L, Parapatics K, Colinge J, Haura EB, Marto JA, Superti-Furga G, Bennett KL, Rix U.
Mol Cancer Ther. 2014 Nov; 13(11):2751-62. PMID: 25189542

The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion.
Dölker N, Górna MW, Sutto L, Torralba AS, Superti-Furga G, Gervasio FL.
PLoS Comput Biol. 2014 Oct; 10(10):e1003863. PMID: 25299346

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.
Winter GE, Radic B, Mayor-Ruiz C, Blomen VA, Trefzer C, Kandasamy RK, Huber KV, Gridling M, Chen D, Klampfl T, Kralovics R, Kubicek S, Fernandez-Capetillo O, Brummelkamp TR, Superti-Furga G.
Nat Chem Biol. 2014 Sep; 10(9):768-73. PMID: 25064833

JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia.
Boztug K, Järvinen PM, Salzer E, Racek T, Mönch S, Garncarz W, Gertz EM, Schäffer AA, Antonopoulos A, Haslam SM, Schieck L, Puchałka J, Diestelhorst J, Appaswamy G, Lescoeur B, Giambruno R, Bigenzahn JW, Elling U, Pfeifer D, Conde CD, Albert MH, Welte K, Brandes G, Sherkat R, van der Werff Ten Bosch J, Rezaei N, Etzioni A, Bellanné-Chantelot C, Superti-Furga G, Penninger JM, Bennett KL, von Blume J, Dell A, Donadieu J, Klein C.
Nat Genet. 2014 Sep; 46(9):1021-7. PMID: 25129144

Toward effective sharing of high-dimensional immunology data.
Snijder B, Kandasamy RK, Superti-Furga G.
Nat Biotechnol. 2014 Aug; 32(8):755-9. PMID: 25101748

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production.
Eberle CA, Zayas M, Stukalov A, Pichlmair A, Alvisi G, Müller AC, Bennett KL, Bartenschlager R, Superti-Furga G.
Virology. 2014 Aug; 462-463:34-41. PMID: 25092459

Building and exploring an integrated human kinase network: global organization and medical entry points.
Colinge J, César-Razquin A, Huber K, Breitwieser FP, Májek P, Superti-Furga G.
J Proteomics. 2014 Jul 31; 107:113-27. PMID: 24704859

Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics.
Giansanti P, Preisinger C, Huber KV, Gridling M, Superti-Furga G, Bennett KL, Heck AJ.
ACS Chem Biol. 2014 Jul 18; 9(7):1490-8. PMID: 24804581

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity.
Upadhyay AS, Vonderstein K, Pichlmair A, Stehling O, Bennett KL, Dobler G, Guo JT, Superti-Furga G, Lill R, Överby AK, Weber F.
Cell Microbiol. 2014 Jun; 16(6):834-48. PMID: 24245804

A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF.
Borgdorff V, Rix U, Winter GE, Gridling M, Müller AC, Breitwieser FP, Wagner C, Colinge J, Bennett KL, Superti-Furga G, Wagner SN.
Oncogene. 2014 May 8; 33(19):2531-9. PMID: 23728343

MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type.
Bonafé L, Liang J, Gorna MW, Zhang Q, Ha-Vinh R, Campos-Xavier AB, Unger S, Beckmann JS, Le Béchec A, Stevenson B, Giedion A, Liu X, Superti-Furga G, Wang W, Spahr A, Superti-Furga A.
Am J Med Genet A. 2014 May; 164A(5):1175-9. PMID: 24648384

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G.
Nature. 2014 Apr 10; 508(7495):222-7. PMID: 24695225
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Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.
Kainulainen M, Habjan M, Hubel P, Busch L, Lau S, Colinge J, Superti-Furga G, Pichlmair A, Weber F.
J Virol. 2014 Mar; 88(6):3464-73. PMID: 24403578

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
Liehl P, Zuzarte-Luís V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Müller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudêncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigário AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM.
Nat Med. 2014 Jan; 20(1):47-53. PMID: 24362933

IFITs: Emerging Roles as Key Anti-Viral Proteins.
Vladimer GI, Górna MW, Superti-Furga G.
Front Immunol. 2014; 5:94. PMID: 24653722



2013


Interactome of two diverse RNA granules links mRNA localization to translational repression in neurons.
Fritzsche R, Karra D, Bennett KL, Ang FY, Heraud-Farlow JE, Tolino M, Doyle M, Bauer KE, Thomas S, Planyavsky M, Arn E, Bakosova A, Jungwirth K, Hörmann A, Palfi Z, Sandholzer J, Schwarz M, Macchi P, Colinge J, Superti-Furga G, Kiebler MA.
Cell Rep. 2013 Dec 26; 5(6):1749-62. PMID: 24360960

Somatic mutations of calreticulin in myeloproliferative neoplasms.
Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD, Them NC, Berg T, Gisslinger B, Pietra D, Chen D, Vladimer GI, Bagienski K, Milanesi C, Casetti IC, Sant'Antonio E, Ferretti V, Elena C, Schischlik F, Cleary C, Six M, Schalling M, Schönegger A, Bock C, Malcovati L, Pascutto C, Superti-Furga G, Cazzola M, Kralovics R.
N Engl J Med. 2013 Dec 19; 369(25):2379-90. PMID: 24325356

Protein interaction networks in innate immunity.
Rebsamen M, Kandasamy RK, Superti-Furga G.
Trends Immunol. 2013 Dec; 34(12):610-9. PMID: 23827258

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
Li J, Bennett K, Stukalov A, Fang B, Zhang G, Yoshida T, Okamoto I, Kim JY, Song L, Bai Y, Qian X, Rawal B, Schell M, Grebien F, Winter G, Rix U, Eschrich S, Colinge J, Koomen J, Superti-Furga G, Haura EB.
Mol Syst Biol. 2013 Nov 5; 9:705. PMID: 24189400

A reversible gene trap collection empowers haploid genetics in human cells.
Bürckstümmer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler FM, Chen D, Them N, Schischlik F, Rebsamen M, Smida M, Fece de la Cruz F, Lapao A, Liszt M, Eizinger B, Guenzl PM, Blomen VA, Konopka T, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, Salic S, Taba Casari MR, Knapp S, Bennett KL, Bock C, Colinge J, Kralovics R, Ammerer G, Casari G, Brummelkamp TR, Superti-Furga G, Nijman SM.
Nat Methods. 2013 Oct; 10(10):965-71. PMID: 24161985

A miniaturized chemical proteomic approach for target profiling of clinical kinase inhibitors in tumor biopsies.
Chamrád I, Rix U, Stukalov A, Gridling M, Parapatics K, Müller AC, Altiok S, Colinge J, Superti-Furga G, Haura EB, Bennett KL.
J Proteome Res. 2013 Sep 6; 12(9):4005-17. PMID: 23901793

Affinity purification strategies for proteomic analysis of transcription factor complexes.
Giambruno R, Grebien F, Stukalov A, Knoll C, Planyavsky M, Rudashevskaya EL, Colinge J, Superti-Furga G, Bennett KL.
J Proteome Res. 2013 Sep 6; 12(9):4018-27. PMID: 23937658

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.
Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.
Nat Methods. 2013 Aug; 10(8):730-6. PMID: 23921808

Experimental characterization of the human non-sequence-specific nucleic acid interactome.
Dürnberger G, Bürckstümmer T, Huber K, Giambruno R, Doerks T, Karayel E, Burkard TR, Kaupe I, Müller AC, Schönegger A, Ecker GF, Lohninger H, Bork P, Bennett KL, Superti-Furga G, Colinge J.
Genome Biol. 2013 Jul 31; 14(7):R81. PMID: 23902751

FAM111A mutations result in hypoparathyroidism and impaired skeletal development.
Unger S, Górna MW, Le Béchec A, Do Vale-Pereira S, Bedeschi MF, Geiberger S, Grigelioniene G, Horemuzova E, Lalatta F, Lausch E, Magnani C, Nampoothiri S, Nishimura G, Petrella D, Rojas-Ringeling F, Utsunomiya A, Zabel B, Pradervand S, Harshman K, Campos-Xavier B, Bonafé L, Superti-Furga G, Stevenson B, Superti-Furga A.
Am J Hum Genet. 2013 Jun 6; 92(6):990-5. PMID: 23684011

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Varjosalo M, Sacco R, Stukalov A, van Drogen A, Planyavsky M, Hauri S, Aebersold R, Bennett KL, Colinge J, Gstaiger M, Superti-Furga G.
Nat Methods. 2013 Apr; 10(4):307-14. PMID: 23455922

Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.
Abbas YM, Pichlmair A, Górna MW, Superti-Furga G, Nagar B.
Nature. 2013 Feb 7; 494(7435):60-4. PMID: 23334420

A method to resolve the composition of heterogeneous affinity-purified protein complexes assembled around a common protein by chemical cross-linking, gel electrophoresis and mass spectrometry.
Rudashevskaya EL, Sacco R, Kratochwill K, Huber ML, Gstaiger M, Superti-Furga G, Bennett KL.
Nat Protoc. 2013 Jan; 8(1):75-97. PMID: 23237831

A target-disease network model of second-generation BCR-ABL inhibitor action in Ph+ ALL.
Rix U, Colinge J, Blatt K, Gridling M, Remsing Rix LL, Parapatics K, Cerny-Reiterer S, Burkard TR, Jäger U, Melo JV, Bennett KL, Valent P, Superti-Furga G.
PLoS One. 2013; 8(10):e77155. PMID: 24130846



2012


Cell biology: a key driver of therapeutic innovation.
Hantschel O, Superti-Furga G.
J Cell Biol. 2012 Nov 12; 199(4):571-5. PMID: 23148230

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML.
Winter GE, Rix U, Carlson SM, Gleixner KV, Grebien F, Gridling M, Müller AC, Breitwieser FP, Bilban M, Colinge J, Valent P, Bennett KL, White FM, Superti-Furga G.
Nat Chem Biol. 2012 Nov; 8(11):905-12. PMID: 23023260

The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL.
Hantschel O, Grebien F, Superti-Furga G.
Cancer Res. 2012 Oct 1; 72(19):4890-5. PMID: 23002203

Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis.
Hopkins S, Linderoth E, Hantschel O, Suarez-Henriques P, Pilia G, Kendrick H, Smalley MJ, Superti-Furga G, Ferby I.
Dev Cell. 2012 Sep 11; 23(3):547-59. PMID: 22975324

Special issue - modular protein domains.
Sudol M, Cesareni G, Superti-Furga G, Just W.
FEBS Lett. 2012 Aug 14; 586(17):2571. PMID: 22713655

Deconvolution of targeted protein-protein interaction maps.
Stukalov A, Superti-Furga G, Colinge J.
J Proteome Res. 2012 Aug 3; 11(8):4102-9. PMID: 22724552

Viral immune modulators perturb the human molecular network by common and unique strategies.
Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G.
Nature. 2012 Jul 26; 487(7408):486-90. PMID: 22810585

A comparative proteomic study of human skin suction blister fluid from healthy individuals using immunodepletion and iTRAQ labeling.
Müller AC, Breitwieser FP, Fischer H, Schuster C, Brandt O, Colinge J, Superti-Furga G, Stingl G, Elbe-Bürger A, Bennett KL.
J Proteome Res. 2012 Jul 6; 11(7):3715-27. PMID: 22578099

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations.
Goncalves A, Karayel E, Rice GI, Bennett KL, Crow YJ, Superti-Furga G, Bürckstümmer T.
Hum Mutat. 2012 Jul; 33(7):1116-22. PMID: 22461318

Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes.
Haura EB, Sacco R, Li J, Müller AC, Grebien F, Superti-Furga G, Bennett KL.
J Integr OMICS. 2012 May; 2(1):55-68. PMID: 24077984

Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression.
Kachaner D, Filipe J, Laplantine E, Bauch A, Bennett KL, Superti-Furga G, Israël A, Weil R.
Mol Cell. 2012 Feb 24; 45(4):553-66. PMID: 22365832

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.
Hantschel O, Warsch W, Eckelhart E, Kaupe I, Grebien F, Wagner KU, Superti-Furga G, Sexl V.
Nat Chem Biol. 2012 Jan 29; 8(3):285-93. PMID: 22286129

Systems biology analysis of protein-drug interactions.
Colinge J, Rix U, Bennett KL, Superti-Furga G.
Proteomics Clin Appl. 2012 Jan; 6(1-2):102-16. PMID: 22213655

Compound immobilization and drug-affinity chromatography.
Rix U, Gridling M, Superti-Furga G.
Methods Mol Biol. 2012; 803:25-38. PMID: 22065216



2011


Targeting allosteric regulatory modules in oncoproteins: 'drugging the undruggable'.
Hantschel O, Grebien F, Superti-Furga G.
Oncotarget. 2011 Nov; 2(11):828-9. PMID: 22084171

Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
Grebien F, Hantschel O, Wojcik J, Kaupe I, Kovacic B, Wyrzucki AM, Gish GD, Cerny-Reiterer S, Koide A, Beug H, Pawson T, Valent P, Koide S, Superti-Furga G.
Cell. 2011 Oct 14; 147(2):306-19. PMID: 22000011
video

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress.
Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ.
Nature. 2011 Oct 5; 478(7367):76-81. PMID: 21979047

An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.
Winter GE, Rix U, Lissat A, Stukalov A, Müllner MK, Bennett KL, Colinge J, Nijman SM, Kubicek S, Kovar H, Kontny U, Superti-Furga G.
Mol Cancer Ther. 2011 Oct; 10(10):1846-56. PMID: 21768330

KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib.
Gleixner KV, Mayerhofer M, Cerny-Reiterer S, Hörmann G, Rix U, Bennett KL, Hadzijusufovic E, Meyer RA, Pickl WF, Gotlib J, Horny HP, Reiter A, Mitterbauer-Hohendanner G, Superti-Furga G, Valent P.
Blood. 2011 Aug 18; 118(7):1885-98. PMID: 21680801

Systems medicine and integrated care to combat chronic noncommunicable diseases.
Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, Agusti A, Brightling C, Cambon-Thomsen A, Cesario A, Abdelhak S, Antonarakis SE, Avignon A, Ballabio A, Baraldi E, Baranov A, Bieber T, Bockaert J, Brahmachari S, Brambilla C, Bringer J, Dauzat M, Ernberg I, Fabbri L, Froguel P, Galas D, Gojobori T, Hunter P, Jorgensen C, Kauffmann F, Kourilsky P, Kowalski ML, Lancet D, Pen CL, Mallet J, Mayosi B, Mercier J, Metspalu A, Nadeau JH, Ninot G, Noble D, Oztürk M, Palkonen S, Préfaut C, Rabe K, Renard E, Roberts RG, Samolinski B, Schünemann HJ, Simon HU, Soares MB, Superti-Furga G, Tegner J, Verjovski-Almeida S, Wellstead P, Wolkenhauer O, Wouters E, Balling R, Brookes AJ, Charron D, Pison C, Chen Z, Hood L, Auffray C.
Genome Med. 2011 Jul 6; 3(7):43. PMID: 21745417

After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.
Huber K, Superti-Furga G.
Bioorg Med Chem. 2011 Jun 15; 19(12):3616-24. PMID: 21306906

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.
Pichlmair A, Lassnig C, Eberle CA, Górna MW, Baumann CL, Burkard TR, Bürckstümmer T, Stefanovic A, Krieger S, Bennett KL, Rülicke T, Weber F, Colinge J, Müller M, Superti-Furga G.
Nat Immunol. 2011 Jun 5; 12(7):624-30. PMID: 21642987

General statistical modeling of data from protein relative expression isobaric tags.
Breitwieser FP, Müller A, Dayon L, Köcher T, Hainard A, Pichler P, Schmidt-Erfurth U, Superti-Furga G, Sanchez JC, Mechtler K, Bennett KL, Colinge J.
J Proteome Res. 2011 Jun 3; 10(6):2758-66. PMID: 21526793

Proteomic analysis of human cataract aqueous humour: Comparison of one-dimensional gel LCMS with two-dimensional LCMS of unlabelled and iTRAQ®-labelled specimens.
Bennett KL, Funk M, Tschernutter M, Breitwieser FP, Planyavsky M, Ubaida Mohien C, Müller A, Trajanoski Z, Colinge J, Superti-Furga G, Schmidt-Erfurth U.
J Proteomics. 2011 Feb 1; 74(2):151-66. PMID: 20940065

Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J.
BMC Syst Biol. 2011 Jan 26; 5:17. PMID: 21269460

Functional dissection of the TBK1 molecular network.
Goncalves A, Bürckstümmer T, Dixit E, Scheicher R, Górna MW, Karayel E, Sugar C, Stukalov A, Berg T, Kralovics R, Planyavsky M, Bennett KL, Colinge J, Superti-Furga G.
PLoS One. 2011; 6(9):e23971. PMID: 21931631



2010


CD14 is a coreceptor of Toll-like receptors 7 and 9.
Baumann CL, Aspalter IM, Sharif O, Pichlmair A, Blüml S, Grebien F, Bruckner M, Pasierbek P, Aumayr K, Planyavsky M, Bennett KL, Colinge J, Knapp S, Superti-Furga G.
J Exp Med. 2010 Nov 22; 207(12):2689-701. PMID: 21078886

A computational approach to analyze the mechanism of action of the kinase inhibitor bafetinib.
Burkard TR, Rix U, Breitwieser FP, Superti-Furga G, Colinge J.
PLoS Comput Biol. 2010 Nov 18; 6(11):e1001001. PMID: 21124949

BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib.
Sherbenou DW, Hantschel O, Kaupe I, Willis S, Bumm T, Turaga LP, Lange T, Dao KH, Press RD, Druker BJ, Superti-Furga G, Deininger MW.
Blood. 2010 Oct 28; 116(17):3278-85. PMID: 20519627

MASPECTRAS 2: An integration and analysis platform for proteomic data.
Ubaida Mohien C, Hartler J, Breitwieser F, Rix U, Remsing Rix L, Winter GE, Thallinger GG, Bennett KL, Superti-Furga G, Trajanoski Z, Colinge J.
Proteomics. 2010 Jul; 10(14):2719-22. PMID: 20455215

Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis.
Blüml S, Binder NB, Niederreiter B, Polzer K, Hayer S, Tauber S, Schett G, Scheinecker C, Kollias G, Selzer E, Bilban M, Smolen JS, Superti-Furga G, Redlich K.
Arthritis Rheum. 2010 Jun; 62(6):1608-19. PMID: 20155834

Peroxisomes are signaling platforms for antiviral innate immunity.
Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC.
Cell. 2010 May 14; 141(4):668-81. PMID: 20451243

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.
Wojcik J, Hantschel O, Grebien F, Kaupe I, Bennett KL, Barkinge J, Jones RB, Koide A, Superti-Furga G, Koide S.
Nat Struct Mol Biol. 2010 Apr; 17(4):519-27. PMID: 20357770

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer.
Li J, Rix U, Fang B, Bai Y, Edwards A, Colinge J, Bennett KL, Gao J, Song L, Eschrich S, Superti-Furga G, Koomen J, Haura EB.
Nat Chem Biol. 2010 Apr; 6(4):291-9. PMID: 20190765

A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells.
Rix U, Remsing Rix LL, Terker AS, Fernbach NV, Hantschel O, Planyavsky M, Breitwieser FP, Herrmann H, Colinge J, Bennett KL, Augustin M, Till JH, Heinrich MC, Valent P, Superti-Furga G.
Leukemia. 2010 Jan; 24(1):44-50. PMID: 19890374



2009


A biomedical adventurers' guide to navigating between careers in academia and industry.
Superti-Furga G.
Nat Rev Mol Cell Biol. 2009 Dec; 10(12):884-7. PMID: 19859061

Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily.
Sillaber C, Herrmann H, Bennett K, Rix U, Baumgartner C, Böhm A, Herndlhofer S, Tschachler E, Superti-Furga G, Jäger U, Valent P.
Eur J Clin Invest. 2009 Dec; 39(12):1098-109. PMID: 19744184

Target profiling of small molecules by chemical proteomics.
Rix U, Superti-Furga G.
Nat Chem Biol. 2009 Sep; 5(9):616-24. PMID: 19690537

The TLR-independent DNA recognition pathway in murine macrophages: Ligand features and molecular signature.
Karayel E, Bürckstümmer T, Bilban M, Dürnberger G, Weitzer S, Martinez J, Superti-Furga G.
Eur J Immunol. 2009 Jul; 39(7):1929-36. PMID: 19551900

Charting the molecular network of the drug target Bcr-Abl.
Brehme M, Hantschel O, Colinge J, Kaupe I, Planyavsky M, Köcher T, Mechtler K, Bennett KL, Superti-Furga G.
PMID: 19380743

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.
Habjan M, Pichlmair A, Elliott RM, Overby AK, Glatter T, Gstaiger M, Superti-Furga G, Unger H, Weber F.
J Virol. 2009 May; 83(9):4365-75. PMID: 19211744

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.
Bürckstümmer T, Baumann C, Blüml S, Dixit E, Dürnberger G, Jahn H, Planyavsky M, Bilban M, Colinge J, Bennett KL, Superti-Furga G.
Nat Immunol. 2009 Mar; 10(3):266-72. PMID: 19158679

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells.
Remsing Rix LL, Rix U, Colinge J, Hantschel O, Bennett KL, Stranzl T, Müller A, Baumgartner C, Valent P, Augustin M, Till JH, Superti-Furga G.
Leukemia. 2009 Mar; 23(3):477-85. PMID: 19039322

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).
Winger JA, Hantschel O, Superti-Furga G, Kuriyan J.
BMC Struct Biol. 2009 Feb 24; 9:7. PMID: 19236722

Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008).
Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, Klingmüller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B.
Mol Oncol. 2009 Feb; 3(1):9-17. PMID: 19383362



2008


Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases.
De Keersmaecker K, Versele M, Cools J, Superti-Furga G, Hantschel O.
Leukemia. 2008 Dec; 22(12):2208-16. PMID: 18784740

A network solution.
Henney A, Superti-Furga G.
Nature. 2008 Oct 9; 455(7214):730-1. PMID: 18843342

Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha.
Baumgartner C, Gleixner KV, Peter B, Ferenc V, Gruze A, Remsing Rix LL, Bennett KL, Samorapoompichit P, Lee FY, Pickl WF, Esterbauer H, Sillaber C, Superti-Furga G, Valent P.
Exp Hematol. 2008 Oct; 36(10):1244-53. PMID: 18619723

The chemokine interleukin-8 and the surface activation protein CD69 are markers for Bcr-Abl activity in chronic myeloid leukemia.
Hantschel O, Gstoettenbauer A, Colinge J, Kaupe I, Bilban M, Burkard TR, Valent P, Superti-Furga G.
Mol Oncol. 2008 Oct; 2(3):272-81. PMID: 19383348

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S.
Cell. 2008 Sep 5; 134(5):793-803. PMID: 18775312

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
Soulat D, Bürckstümmer T, Westermayer S, Goncalves A, Bauch A, Stefanovic A, Hantschel O, Bennett KL, Decker T, Superti-Furga G.
EMBO J. 2008 Aug 6; 27(15):2135-46. PMID: 18583960

Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia.
Sherbenou DW, Hantschel O, Turaga L, Kaupe I, Willis S, Bumm T, Press RD, Superti-Furga G, Druker BJ, Deininger MW.
Leukemia. 2008 Jun; 22(6):1184-90. PMID: 18354488

Finally: The digital, democratic age of scientific abstracts.
Superti-Furga G, Wieland F, Cesareni G.
FEBS Lett. 2008 Apr 9; 582(8):1169. PMID: 18328821

Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib.
Hantschel O, Rix U, Superti-Furga G.
Leuk Lymphoma. 2008 Apr; 49(4):615-9. PMID: 18398720

The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils.
Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P.
Blood. 2008 Mar 15; 111(6):3097-107. PMID: 18180381

Human Proteinpedia enables sharing of human protein data.
Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States.
PMID: 18259167

Drugs in action.
Eggert US, Superti-Furga G.
Nat Chem Biol. 2008 Jan; 4(1):7-11. PMID: 18084271



2007


Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets.
Rix U, Hantschel O, Dürnberger G, Remsing Rix LL, Planyavsky M, Fernbach NV, Kaupe I, Bennett KL, Valent P, Colinge J, Köcher T, Superti-Furga G.
Blood. 2007 Dec 1; 110(12):4055-63. PMID: 17720881

Selective serotonin reuptake inhibitors--a new modality for the treatment of lymphoma/leukaemia?
Schuster C, Fernbach N, Rix U, Superti-Furga G, Holy M, Freissmuth M, Sitte HH, Sexl V.
PMID: 17709099

Mass spectrometry-based functional proteomics: from molecular machines to protein networks.
Köcher T, Superti-Furga G.
Nat Methods. 2007 Oct; 4(10):807-15. PMID: 17901870

The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib.
Hantschel O, Rix U, Schmidt U, Bürckstümmer T, Kneidinger M, Schütze G, Colinge J, Bennett KL, Ellmeier W, Valent P, Superti-Furga G.
PMID: 17684099

The minimum information required for reporting a molecular interaction experiment (MIMIx).
Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H.
Nat Biotechnol. 2007 Aug; 25(8):894-8. PMID: 17687370



2006


Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.
Angrand PO, Segura I, Völkel P, Ghidelli S, Terry R, Brajenovic M, Vintersten K, Klein R, Superti-Furga G, Drewes G, Kuster B, Bouwmeester T, Acker-Palmer A.
Mol Cell Proteomics. 2006 Dec; 5(12):2211-27. PMID: 16959763

An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells.
Bürckstümmer T, Bennett KL, Preradovic A, Schütze G, Hantschel O, Superti-Furga G, Bauch A.
Nat Methods. 2006 Dec; 3(12):1013-9. PMID: 17060908

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.
Cursi S, Rufini A, Stagni V, Condò I, Matafora V, Bachi A, Bonifazi AP, Coppola L, Superti-Furga G, Testi R, Barilà D.
EMBO J. 2006 May 3; 25(9):1895-905. PMID: 16619028

Cytoplasmic Listeria monocytogenes stimulates IFN-beta synthesis without requiring the adapter protein MAVS.
Soulat D, Bauch A, Stockinger S, Superti-Furga G, Decker T.
FEBS Lett. 2006 Apr 17; 580(9):2341-2346. PMID: 16616525

Charting protein complexes, signaling pathways, and networks in the immune system.
Bauch A, Superti-Furga G.
Immunol Rev. 2006 Apr; 210:187-207. PMID: 16623772

Proteome survey reveals modularity of the yeast cell machinery.
Gavin AC, Aloy P, Grandi P, Krause R, Boesche M, Marzioch M, Rau C, Jensen LJ, Bastuck S, Dümpelfeld B, Edelmann A, Heurtier MA, Hoffman V, Hoefert C, Klein K, Hudak M, Michon AM, Schelder M, Schirle M, Remor M, Rudi T, Hooper S, Bauer A, Bouwmeester T, Casari G, Drewes G, Neubauer G, Rick JM, Kuster B, Bork P, Russell RB, Superti-Furga G.
Nature. 2006 Mar 30; 440(7084):631-6. PMID: 16429126

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Nagar B, Hantschel O, Seeliger M, Davies JM, Weis WI, Superti-Furga G, Kuriyan J.
Mol Cell. 2006 Mar 17; 21(6):787-98. PMID: 16543148



2005


Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl.
Hantschel O, Wiesner S, Güttler T, Mackereth CD, Rix LL, Mikes Z, Dehne J, Görlich D, Sattler M, Superti-Furga G.
Mol Cell. 2005 Aug 19; 19(4):461-73. PMID: 16109371

NMR Assignment Reveals an alpha-Helical Fold for the F-Actin Binding Domain of Human Bcr-Abl/c-Abl.
Wiesner S, Hantschel O, Mackereth CD, Superti-Furga G, Sattler M.
J Biomol NMR. 2005 Aug; 32(4):335. PMID: 16211486



2004


RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane.
Sandilands E, Cans C, Fincham VJ, Brunton VG, Mellor H, Prendergast GC, Norman JC, Superti-Furga G, Frame MC.
Dev Cell. 2004 Dec; 7(6):855-69. PMID: 15572128

Structure-based assembly of protein complexes in yeast.
Aloy P, Böttcher B, Ceulemans H, Leutwein C, Mellwig C, Fischer S, Gavin AC, Bork P, Superti-Furga G, Serrano L, Russell RB.
Science. 2004 Mar 26; 303(5666):2026-9. PMID: 15044803

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G.
Nat Cell Biol. 2004 Feb; 6(2):97-105. PMID: 14743216

Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
Hantschel O, Superti-Furga G.
Nat Rev Mol Cell Biol. 2004 Jan; 5(1):33-44. PMID: 14708008



2003


Rediscovering the sweet spot in drug discovery.
Brown D, Superti-Furga G.
Drug Discov Today. 2003 Dec 1; 8(23):1067-77. PMID: 14693466

ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins.
Puntervoll P, Linding R, Gemünd C, Chabanis-Davidson S, Mattingsdal M, Cameron S, Martin DM, Ausiello G, Brannetti B, Costantini A, Ferrè F, Maselli V, Via A, Cesareni G, Diella F, Superti-Furga G, Wyrwicz L, Ramu C, McGuigan C, Gudavalli R, Letunic I, Bork P, Rychlewski L, Küster B, Helmer-Citterich M, Hunter WN, Aasland R, Gibson TJ.
Nucleic Acids Res. 2003 Jul 1; 31(13):3625-30. PMID: 12824381

Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae.
Takashima Y, Delfino FJ, Engen JR, Superti-Furga G, Smithgall TE.
Biochemistry. 2003 Apr 1; 42(12):3567-74. PMID: 12653561

Caspase-dependent cleavage of c-Abl contributes to apoptosis.
Barilà D, Rufini A, Condò I, Ventura N, Dorey K, Superti-Furga G, Testi R.
Mol Cell Biol. 2003 Apr; 23(8):2790-9. PMID: 12665579

A myristoyl/phosphotyrosine switch regulates c-Abl.
Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G.
Cell. 2003 Mar 21; 112(6):845-57. PMID: 12654250

Structural basis for the autoinhibition of c-Abl tyrosine kinase.
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J.
Cell. 2003 Mar 21; 112(6):859-71. PMID: 12654251

Protein complexes and proteome organization from yeast to man.
Gavin AC, Superti-Furga G.
Curr Opin Chem Biol. 2003 Feb; 7(1):21-7. PMID: 12547422



2002


Phosphorylation of Bruton's tyrosine kinase by c-Abl.
Bäckesjö CM, Vargas L, Superti-Furga G, Smith CI.
PMID: 12445832

High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system.
Mandine E, Jean-Baptiste V, Vayssière B, Gofflo D, Bénard D, Sarubbi E, Deprez P, Baron R, Superti-Furga G, Lesuisse D.
PMID: 12387813

c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.
Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW.
Mol Cell Biol. 2002 Jul; 22(13):4535-43. PMID: 12052863

A complex prediction: three-dimensional model of the yeast exosome.
Aloy P, Ciccarelli FD, Leutwein C, Gavin AC, Superti-Furga G, Bork P, Bottcher B, Russell RB.
EMBO Rep. 2002 Jul; 3(7):628-35. PMID: 12101094

c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis.
Furstoss O, Dorey K, Simon V, Barilà D, Superti-Furga G, Roche S.
EMBO J. 2002 Feb 15; 21(4):514-24. PMID: 11847100

Autoinhibition of c-Abl.
Pluk H, Dorey K, Superti-Furga G.
Cell. 2002 Jan 25; 108(2):247-59. PMID: 11832214

Functional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin AC, Bösche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Höfert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G.
Nature. 2002 Jan 10; 415(6868):141-7. PMID: 11805826



2001


Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase.
Dorey K, Engen JR, Kretzschmar J, Wilm M, Neubauer G, Schindler T, Superti-Furga G.
Oncogene. 2001 Dec 6; 20(56):8075-84. PMID: 11781820

Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation.
Young MA, Gonfloni S, Superti-Furga G, Roux B, Kuriyan J.
Cell. 2001 Apr 6; 105(1):115-26. PMID: 11301007



2000


Nuclear tyrosine phosphorylation: the beginning of a map.
Cans C, Mangano R, Barilá D, Neubauer G, Superti-Furga G.
Biochem Pharmacol. 2000 Oct 15; 60(8):1203-15. PMID: 11007959

Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway.
Blondeau F, Laporte J, Bodin S, Superti-Furga G, Payrastre B, Mandel JL.
Hum Mol Genet. 2000 Sep 22; 9(15):2223-9. PMID: 11001925

Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src.
Gonfloni S, Weijland A, Kretzschmar J, Superti-Furga G.
Nat Struct Biol. 2000 Apr; 7(4):281-6. PMID: 10742171

A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.
Barilá D, Mangano R, Gonfloni S, Kretzschmar J, Moro M, Bohmann D, Superti-Furga G.
EMBO J. 2000 Jan 17; 19(2):273-81. PMID: 10637231



1999


Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling.
Frischknecht F, Moreau V, Röttger S, Gonfloni S, Reckmann I, Superti-Furga G, Way M.
Nature. 1999 Oct 28; 401(6756):926-9. PMID: 10553910

Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
Gonfloni S, Frischknecht F, Way M, Superti-Furga G.
Nat Struct Biol. 1999 Aug; 6(8):760-4. PMID: 10426955

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
Mason CS, Springer CJ, Cooper RG, Superti-Furga G, Marshall CJ, Marais R.
EMBO J. 1999 Apr 15; 18(8):2137-48. PMID: 10205168

Regulation of human c-Abl tyrosine kinase activity in Xenopus oocytes and acceleration of progesterone-induced G2/M transition by oncogenic forms.
Dorey K, Barilá D, Gavin AC, Nebreda AR, Superti-Furga G.
Biol Chem. 1999 Feb; 380(2):223-30. PMID: 10195429



1998


An intramolecular SH3-domain interaction regulates c-Abl activity.
Barilá D, Superti-Furga G.
Nat Genet. 1998 Mar; 18(3):280-2. PMID: 9500553



1997


The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions.
Williams JC, Weijland A, Gonfloni S, Thompson A, Courtneidge SA, Superti-Furga G, Wierenga RK.
J Mol Biol. 1997 Dec 19; 274(5):757-75. PMID: 9405157

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.
Gonfloni S, Williams JC, Hattula K, Weijland A, Wierenga RK, Superti-Furga G.
EMBO J. 1997 Dec 15; 16(24):7261-71. PMID: 9405355

A crystal milestone: the structure of regulated Src.
Superti-Furga G, Gonfloni S.
Bioessays. 1997 Jun; 19(6):447-50. PMID: 9204760

Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?
Baldin V, Cans C, Superti-Furga G, Ducommun B.
PMID: 9188863

Src regulated by C-terminal phosphorylation is monomeric.
Weijland A, Williams JC, Neubauer G, Courtneidge SA, Wierenga RK, Superti-Furga G.
PMID: 9108021

A functional screen for regulators of the c-Abl protein tyrosine kinase.
Moro M, Walkenhorst J, Goga A, Witte ON, Superti-Furga G.
Leukemia. 1997 Apr; 11 Suppl 3:313-5. PMID: 9209375

The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins.
Mandl B, Brandt WF, Superti-Furga G, Graninger PG, Birnstiel ML, Busslinger M.
Mol Cell Biol. 1997 Mar; 17(3):1189-200. PMID: 9032246

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
Migliaccio E, Mele S, Salcini AE, Pelicci G, Lai KM, Superti-Furga G, Pawson T, Di Fiore PP, Lanfrancone L, Pelicci PG.
EMBO J. 1997 Feb 17; 16(4):706-16. PMID: 9049300



1996


The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway.
Toda T, Dhut S, Superti-Furga G, Gotoh Y, Nishida E, Sugiura R, Kuno T.
Mol Cell Biol. 1996 Dec; 16(12):6752-64. PMID: 8943330

The purification and characterization of the catalytic domain of Src expressed in Schizosaccharomyces pombe. Comparison of unphosphorylated and tyrosine phosphorylated species.
Weijland A, Neubauer G, Courtneidge SA, Mann M, Wierenga RK, Superti-Furga G.
Eur J Biochem. 1996 Sep 15; 240(3):756-64. PMID: 8856081

Growth controllers knocked out.
Superti-Furga G.
Trends Genet. 1996 Aug; 12(8):324-5. PMID: 8783946

A functional screen in yeast for regulators and antagonizers of heterologous protein tyrosine kinases.
Superti-Furga G, Jönsson K, Courtneidge SA.
Nat Biotechnol. 1996 May; 14(5):600-5. PMID: 9630950

Analysis of human c-Abl tyrosine kinase activity and regulation in S. pombe.
Walkenhorst J, Goga A, Witte ON, Superti-Furga G.
Oncogene. 1996 Apr 4; 12(7):1513-20. PMID: 8622867



1995


Structural requirements for the efficient regulation of the Src protein tyrosine kinase by Csk.
Koegl M, Courtneidge SA, Superti-Furga G.
Oncogene. 1995 Dec 7; 11(11):2317-29. PMID: 8570183

Regulation of the Src protein tyrosine kinase.
Superti-Furga G.
FEBS Lett. 1995 Aug 1; 369(1):62-6. PMID: 7641886

Structure-function relationships in Src family and related protein tyrosine kinases.
Superti-Furga G, Courtneidge SA.
Bioessays. 1995 Apr; 17(4):321-30. PMID: 7537961

Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions.
Erpel T, Superti-Furga G, Courtneidge SA.
EMBO J. 1995 Mar 1; 14(5):963-75. PMID: 7534229



1993


Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.
Superti-Furga G, Fumagalli S, Koegl M, Courtneidge SA, Draetta G.
EMBO J. 1993 Jul; 12(7):2625-34. PMID: 7687537

The Src family of protein tyrosine kinases: regulation and functions.
Courtneidge SA, Fumagalli S, Koegl M, Superti-Furga G, Twamley-Stein GM.
Dev Suppl. 1993; :57-64. PMID: 8049488



1992


Identification of Fos target genes by the use of selective induction systems.
Braselmann S, Bergers G, Wrighton C, Graninger P, Superti-Furga G, Busslinger M.
J Cell Sci Suppl. 1992; 16:97-109. PMID: 1297655



1989


The testis-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa.
Barberis A, Superti-Furga G, Busslinger M.
Nucleic Acids Res. 1989 Sep 12; 17(17):7114. PMID: 2780325

The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein.
Mantovani R, Superti-Furga G, Gilman J, Ottolenghi S.
Nucleic Acids Res. 1989 Aug 25; 17(16):6681-91. PMID: 2476717

Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin.
Barberis A, Superti-Furga G, Vitelli L, Kemler I, Busslinger M.
Genes Dev. 1989 May; 3(5):663-75. PMID: 2744459

The protein CDP, but not CP1, footprints on the CCAAT region of the gamma-globin gene in unfractionated B-cell extracts.
Superti-Furga G, Barberis A, Schreiber E, Busslinger M.
Biochim Biophys Acta. 1989 Mar 1; 1007(2):237-42. PMID: 2784063



1988


The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene.
Superti-Furga G, Barberis A, Schaffner G, Busslinger M.
EMBO J. 1988 Oct; 7(10):3099-107. PMID: 3181130