Scientist IMI Project in Transporter Cell Line Engineering
The Superti-Furga laboratory at CeMM in Vienna is contributing to the scientific fundaments of precision medicine by studying drug action at the systems-level. In recent years, the laboratory has focused on understanding how membrane transporters govern access to nutrients, ions, xenobiotcis and drugs for cells and organisms. Regulation of the function of transporters is integrated with metabolic processes, brokering internal demand and external offer. Specificity, regulation and functional integration of the roughly 1,500 human genes encoding various types of transporters is only poorly understood. The Superti-Furga laboratory is particularly interested in the > 400 members of the Solute Carrier Proteins super group (SLCs), as they contain some highly prominent drug targets and drug transporters, are involved in numerous diseases, but are dramatically understudied (César-Razquin et al. Cell 2015). According to the mission of the laboratory, SLCs can be considered the managers of the interface between chemistry and biology, and between organisms and their environment. Consequently, studying their regulation is of fundamental importance for biology and medicine.
The Innovative Medicine Initiative (IMI) is an EU public-private partnership funding health research and innovation. As part of an IMI-supported effort aiming at “unlocking” the SLC target class and involving a consortium of several leading academic laboratories and pharmaceutical companies, we are currently searching for a highly motivated PhD-level Scientist who wants to contribute to this exciting open science quest involving a large group of scientists and, ultimately, the whole interested scientific community. Your main assignment will be to generate the large battery of engineered cell lines that are the biological tools standing at the beginning of the entire workflow. You will use cutting edge genome engineering technologies. This position offers a nearly perfect mix of organizational/managerial tasks and wet-lab work, and is a fantastic opportunity for scientists with profound knowledge of generation and organization of engineered cell lines, who want to seize the opportunity to create, navigate, integrate, visualize and interpret original data in innovative ways and for a large group of collaborating scientists.
In this role, you will supervise and coordinate a small team of technical assistants and you will help them implement SOPs. To complement our creative group of scientists you should be a team player with strong organization skills who would like to develop his/her management skills and who strives for top performance day by day. If, beyond that, you have a structured and efficient work style and you are eager to team up with experimental scientists in the Superti-Furga laboratory as well as with laboratories that are part of the international network of academic and industrial partners, you are the perfect asset for our team.
Your main tasks and responsibilities include:
- Establishment of a pipeline for the rapid generation of engineered human cell lines (knock-out and over-expression)
- Generation of standard operating procedures (SOPs)
- Characterization of the engineered cell lines
- Organization of the growing cell line collection
- Supervision and management of a small team of technical assistants
- Technology development as team effort
- Training of new lab members
- Perfect record keeping and report writing
- Contribute to expert computational analysis and data visualization
- Presentation at local and international team meetings as well as externally at seminars and conferences
Requirements and desired qualifications:
- PhD degree in biology, chemistry or a medical degree
- Relevant work experience in experimental biomedical research
- Knowledge of mammalian cell culture techniques
- Mastering of molecular biology techniques (PCR, genotyping, immunoblotting, cloning)
- Experience in sequence analysis using basic bioinformatics tools (blast, reading of trace files, TIDE)
- Excellent English skills, both written and spoken, and very good communication skills
- Propensity to be highly accurate and organized
- Structured and efficient work style
- Distinctive social competence
- Experience with viral delivery systems, CRISPR/Cas9 and Flp-In technologies is considered an advantage
- Previous managerial experience is desirable
Why you want to join our team:
- This is a great opportunity for an advanced scientist to join an exciting project in an inspiring and dynamic biomedical research setting.
- You would like to work alongside with international, innovative researchers from industry and academy to shape the future of medicine.
- You are looking for an inclusive workplace with a highly positive and motivating work climate and you appreciate the possibility to join our cultural, social and sports activities.
- We are happy to provide help and assistance to all our employees, their spouses and family members in terms of visa and relocation procedures, dual-career and childcare services, and others.
- We offer a fair employee benefits package including health insurance, company health care, competitive holiday allowance, daily bonus for the in-house cafeteria and an annual gross salary (according to the FWF personnel costs scheme https://www.fwf.ac.at/en/research-funding/personnel-costs/, depending on qualifications and experience).
- This position is planned for the initial project duration of 3 years.
CeMM is an international research institute of the Austrian Academy of Sciences and founding member of EU-LIFE (http://eu-life.eu), an association of leading biomedical research institutes in Europe. CeMM has an outstanding scientific track record (last five years: >10 papers in Nature/Cell/Science/NEJM, >25 papers in Nature/Cell sister journals), medical translation, and spin-off companies. CeMM provides a truly collaborative (http://cemm.at/career/why-work-at-cemm/collaborative-work-environment/) and personal environment, while maintaining critical mass and all relevant technologies. Research at CeMM focuses on cancer, inflammation, and immune disorders. CeMM is located at the center of one of the largest medical campuses in Europe, within walking distance of Vienna’s historical city center. A study by “The Scientist” placed CeMM among the top-5 best places to work in academia worldwide (http://the-scientist.com/2012/08/01/best-places-to-work-academia-2012). Vienna is an international city with a large English-speaking community and frequently ranked the world’s best city to live. The official language at CeMM is English, and more than 40 nationalities are represented. CeMM aims to promote equality of opportunity for all with the right mix of talent, competences, and potential thus we welcome applications from candidates with diverse backgrounds.
Please apply online with a cover letter explaining why you are the ideal candidate for this position, your detailed curriculum vitae and contact details of 2-3 referees. Please upload your full application and click on "apply now".
Ideally, you should please submit one Pdf file containing all of your application documents. Initial application deadline is April 8, 2018 but the call will remain open until the position is filled. Candidates will be contacted by us on a rolling basis.
Application Deadline:8 April 2018
Applicants should submit:
One Pdf file containing all of your application documents. Initial application deadline is April 8, 2018 but the call will remain open until the position is filled.