Pharmacoscopy – Watching drug action under the microscope

 

Lipidome - The code of how cellular lipids are co-regulated

Köberlin & Snijder et al. 2015 / Heinz & Baumann et al. 2015 

At the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, researchers from the team of Giulio Superti-Furga, have discovered that the regulation of lipids in the cell membrane follows a surprising circular, ring-like organizational pattern and that this pattern is linked to various cellular functions. In particular, the scientists found that the ability of cells to mount an immediate immune response is influenced by the cell’s lipid composition to a degree that far exceeds what had been known to date and can be predicted by this new regulatory “code”.

Their findings of two studies published the renowned scientific journals Cell and Cell Reports on June 18th 2015.

SLC38A9 - A component of the lysosomal amino acid sensing machinery that controls mTORC1

Rebsamen et al. 2015

Novel strategy to molecular anticancer therapy tricks malignant cells

 

Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis